HIV entry blocker pairs CD4 mimic and antibody, showing sevenfold higher efficacy

Drug conjugates (ADCs) developed at Institute of Science Tokyo combine a CD4 mimic with neutralizing antibodies for enhanced suppression of human immunodeficiency virus (HIV) infection. By targeting ...
European Medical Journal

Targeting Hidden HIV Reservoir Clones for Future Cure Strategies

Study dissects HIV reservoir clones that persist on ART, revealing how CD8+ T cells and resistance pathways could be harnessed for future cure strategies.

Single Daily Tablet Shows Powerful Results for People With Drug-Resistant HIV

A large international clinical trial has unveiled a promising new option for people living with highly treatment-resistant HIV.
Fred Hutch

HIV’s secret sweet tooth: T cell glycosylation determines variant entry

At the cellular level, HIV-1 transmission involves a highly coordinated process whereby the virus binds to CD4 receptors and one of two coreceptors—CCR5 (R5) or CXCR4 (X4)—on host immune cells, ...
HUB

Patient sees dramatic drop in HIV-infected immune cells after cancer treatment

Advancements in HIV/AIDS research, drug development, and clinical practice since the 1980s have made it possible for people living with HIV to lead long, productive lives and keep the virus in check ...