The serine/threonine kinase LKB1 is ubiquitously expressed and highly conserved throughout evolution. It has been demonstrated to function as a ‘master kinase’ potentially activating several ...
Germ line mutations in the LKB1 tumor suppressor gene are associated with the Peutz–Jeghers polyposis and cancer syndrome. Somatic mutations in Lkb1 are observed in sporadic pulmonary, pancreatic and ...
Figure 1. Tumor suppressing pathways of LKB1. The LKB1-AMPK-mTOR pathway suppresses tumor development. LKB1-AMPK disrupt mTOR activity leading to decreased survival and proliferation while increasing ...
The alteration frequency including mutations, structural variants, amplifications, deep deletions, and multiple alterations of LKB1 in tumors. Listed in descending prevalence are LKB1 genetic ...
Mutations in serine-threonine kinase 11 (STK11) and liver kinase B1 (LKB1) are associated with disease progression in Peutz-Jeghers syndrome (PJS), which can progress to cancer. Previous studies have ...
A brief overview of the physiological and pathological role of LKB1 signaling. Mutations in serine-threonine kinase 11 (STK11) and liver kinase B1 (LKB1) are associated with disease progression in ...
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